解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The TNF family molecule RANKL and its receptor RANK are key regulators of bone remodeling, lymph node formation, and mammary gland development during pregnancy. RANKL and RANK are also expressed in the central nervous systems (CNS). However, the functional relevance of RANKL/RANK in the brain was entirely unknown. Rec...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2010.149
更新日期:2010-12-01 00:00:00
abstract::The formation of reactive oxygen species (ROS) can be induced by xenobiotic substances, such as redox cycling molecules, but also by endogenous substances such as hormones and cytokines. Recent research shows the importance of ROS in cellular signaling. Here, the signaling pathways of the two blood pressure-regulating...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2010.136
更新日期:2010-11-01 00:00:00
abstract::The glutamyl endopeptidase family of enzymes from staphylococci has been shown to be important virulence determinants of pathogenic family members, such as Staphylococcus aureus. Previous studies have identified the N-terminus and residues from positions 185-195 as potentially important regions that determine the acti...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2010.116
更新日期:2010-10-01 00:00:00
abstract::The mitochondrial DNA (mtDNA) encompasses two classes of functionally important sequence variants: recent pathogenic mutations and ancient adaptive polymorphisms. To rapidly and cheaply evaluate both classes of single nucleotide variants (SNVs), we have developed an integrated system in which mtDNA SNVs are analyzed b...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2010.125
更新日期:2010-10-01 00:00:00
abstract::Here we report a detailed analysis of magnesium (Mg²+) ion effects on furin hydrolysis of fluorescent resonance energy transfer decapeptide substrates derived from canonical R-X-K/R-R furin cleavage motifs within certain viral envelope glycoproteins and eukaryotic proproteins. Using virus-derived sequences a selective...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2010.114
更新日期:2010-09-01 00:00:00
abstract::The adipocytokine adiponectin and its receptor (AdipoR) comprise a new receptor-ligand system that is involved in a variety of clinically important morbidities such as obesity, type 2 diabetes and cardiovascular diseases. Adiponectin exerts a multitude of beneficial and tissue specific effects depending on its unique,...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2010.104
更新日期:2010-09-01 00:00:00
abstract::Xeroderma pigmentosum complementation group D protein (XPD) is an iron-sulfur cluster containing 5'-3' helicase and, in humans, part of the transcription factor TFIIH. TFIIH is involved in nucleotide excision repair as well as in transcription initiation. Recently, three different groups have reported the structures o...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2010.076
更新日期:2010-07-01 00:00:00
abstract::Small-angle scattering (SAS) of X-rays and neutrons reveals low-resolution structures of biological macromolecules in solution. With the recent experimental and methodological advances, SAS became a unique tool for characterising biological systems. The method covers an extremely broad range of molecule sizes (from a ...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2010.093
更新日期:2010-07-01 00:00:00
abstract::Cancer cells are relatively resistant to endoplasmic reticulum (ER) stress-induced apoptosis. However, the underlying mechanisms remain largely unclear. We observed that the microRNAs miR-221/222 are associated with apoptosis regulation under ER stress in human hepatocellular carcinoma (HCC) cells. Induction of ER str...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2010.072
更新日期:2010-07-01 00:00:00
abstract::Abstract The homeostasis and atheroprotective function of bilirubin could be an appealing model to investigate one of the many physiologic functions of the human aryl hydrocarbon receptor (AhR). Several clinical and epidemiological studies have been carried out on key enzymes generating and eliminating bilirubin (heme...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2010.065
更新日期:2010-06-01 00:00:00
abstract::Molecular chaperones are well known as facilitators of protein folding and assembly. However, in recent years multiple chaperone-assisted degradation pathways have also emerged, including CAP (chaperone-assisted proteasomal degradation), CASA (chaperone-assisted selective autophagy), and CMA (chaperone-mediated autoph...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2010.058
更新日期:2010-05-01 00:00:00
abstract::Kallikrein-related peptidase 2 (KLK2) degrades insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in vitro. IGFBP-3 forms complexes with IGFs, preventing them from binding to their receptors and stimulating cell proliferation and survival. IGF-independent actions have also been described for IGFBP-3. The deg...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2010.039
更新日期:2010-04-01 00:00:00
abstract::The kallikrein-kinin and renin-angiotensin (KKS-RAS) systems represent two highly regulated proteolytic systems that are involved in several physiological and pathological processes. Although their protein-protein interactions can be studied using experimental approaches, it is difficult to differentiate between direc...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2010.046
更新日期:2010-04-01 00:00:00
abstract::A central point of regulation in the Wnt/beta-catenin signalling pathway is the formation of the beta-catenin destruction complex. Axin1, an essential negative regulator of Wnt signalling, serves as a scaffold within this complex and is critical for rapid turnover of beta-catenin. To examine the mechanism by which Wnt...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2010.028
更新日期:2010-02-01 00:00:00
abstract::This article presents a historical account of the discovery of reversible protein phosphorylation. The process was uncovered in the mid-1950s in a study designed to elucidate the complex hormonal regulation of skeletal muscle glycogen phosphorylase. This enzyme was originally thought to be regulated by AMP now known t...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2010.011
更新日期:2010-02-01 00:00:00
abstract::Bacterial infections often upregulate the plasma kinin-forming cascade of the host (the 'contact system') which is triggered by adsorption of high molecular mass kininogen (HK), coagulation factor XII (FXII) and prekallikrein (pHPK) on the host or pathogen cell surfaces. A possible activation of the contact system upo...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2009.145
更新日期:2010-01-01 00:00:00
abstract::Cytokinins are essential plant hormones that regulate numerous physiological processes. Recently, a protein was identified in mung bean (Vigna radiata) and characterized as a cytokinin-specific binding protein (VrCSBP). Fluorescence correlation spectroscopy was used to investigate the interaction between VrCSBP and it...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2010.005
更新日期:2010-01-01 00:00:00
abstract::The flagellate Euglena gracilis contains as photoreceptor complex a heterotetrameric light-sensitive adenylyl cyclase (AC), consisting of the flavoproteins PACalpha and PACbeta. Previously, we demonstrated the functional expression of PACalpha and PACbeta in oocytes from Xenopus laevis and of PACalpha in different ani...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2009.132
更新日期:2009-11-01 00:00:00
abstract::The periplasmic ligand-binding protein ChoX is part of the ABC transport system ChoVWX that imports choline as a nutrient into the soil bacterium Sinorhizobium meliloti. We have recently reported the crystal structures of ChoX in complex with its ligands choline and acetylcholine and the structure of a fully closed bu...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2009.113
更新日期:2009-11-01 00:00:00
abstract::In preeclampsia and hemolysis, elevated liver enzymes and low platelet (HELLP) syndrome, impaired trophoblast invasion and excessive fibrin deposition in the placental intervillous space is associated with fetal compromise. However, little information is available whether modulation of placental protease expression--p...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2009.123
更新日期:2009-11-01 00:00:00
abstract::Recent evidence suggests that epidermal growth factor receptor (EGFR)-dependent signaling contributes to liver cell proliferation, as well as to apoptotic liver cell death, and represents an important regulator of hepatic regeneration. This article summarizes recent findings on the molecular mechanisms involved in EGF...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2009.106
更新日期:2009-10-01 00:00:00
abstract::Extreme thermophiles produce unusually long polyamines, including the linear caldopentamine (Cdp) and the branched pentamine tetrakis(3-aminopropyl)-ammonium (Taa), with the latter containing a central quaternary ammonium moiety. Here we compare the interaction of these two pentamines with RNA by studying the heat den...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2009.096
更新日期:2009-09-01 00:00:00
abstract::Bradykinin (BK) is a vasorelaxant, algesic and inflammatory agent. Angiotensin II (AngII) is known to control vascular tone and promote growth, inflammation and artherogenesis. There is evidence for cross talking between BK and AngII receptors. Therefore, the effect of lack of kinin receptors was assessed in mice with...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2009.081
更新日期:2009-09-01 00:00:00
abstract::Protein transport, especially into different cellular compartments, is a highly coordinated and regulated process. The molecular machineries which carry out these transport processes are highly complex in structure, function, and regulation. In the case of chloroplasts, thousands of protein molecules have been estimat...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2009.051
更新日期:2009-08-01 00:00:00
abstract::A major challenge in the research on membrane-anchored and integral membrane protein complexes is to obtain these in a functionally active, water-soluble, and monodisperse form. This requires the incorporation of the membrane proteins into a native-like membrane or detergent micelle that mimics the properties of the o...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2009.091
更新日期:2009-08-01 00:00:00
abstract::Human adenocarcinomas overexpress a hypoglycosylated, tumor-associated form of the mucin-like glycoprotein MUC1 containing abnormal mono- and disaccharide antigens, such as Tn, sialyl-Tn, and TF, as well as stretches of unglycosylated protein backbone in the variable number of tandem repeats (VNTR) region. Both peptid...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2009.070
更新日期:2009-07-01 00:00:00
abstract::We have previously shown that short double-stranded RNAs of specific sequence induce phosphorylation in the activation loop of splicing variant D of the transforming growth factor beta-activated protein kinase 1 (TAK1-D). Here, we further characterize this novel function of TAK1-D and the mechanisms of this dsRNA-trig...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2009.046
更新日期:2009-05-01 00:00:00
abstract::The efficient execution of apoptotic cell death with the clearance of apoptotic debris by phagocytes is a key regulatory mechanism ensuring tissue homeostasis. Failure in this execution program contributes to the pathogenesis of many human diseases. In this review, we describe the current knowledge regarding the inter...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2009.048
更新日期:2009-05-01 00:00:00
abstract::The average amount of cholesterol in the whole animal equals approximately 2100 mg/kg body weight, and 15% and 23% of this sterol in the mouse and human, respectively, is found in the central nervous system. There is no detectable uptake across the blood-brain barrier of cholesterol carried in lipoproteins in the plas...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2009.035
更新日期:2009-04-01 00:00:00
abstract::Molecular chaperones of the heat shock protein 70 (Hsp70) family play a crucial role in the presentation of exogenous antigenic peptides by antigen-presenting cells (APCs). In a combined biochemical and immunological approach, we characterize the biochemical interaction of tumor-associated peptides with human Hsp70 an...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2009.038
更新日期:2009-04-01 00:00:00
abstract::Knockout mice are the gold standard to probe for the role of a specific protease within the interacting network of proteases, substrates, and inhibitors. This proteolytic network, or protease web, determines cell signaling and organ homeostasis. Therefore, protease deficiency or inhibition is intrinsically tied to alt...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2009.015
更新日期:2009-02-01 00:00:00
abstract::Metachromatic leukodystrophy is a lysosomal disorder caused by the deficiency of arylsulfatase A (ASA). This leads to the storage of the sphingolipid 3-O-sulfogalactosylceramide (sulfatide) in various cell types, such as renal tubular cells. Examination of mannose 6-phosphate receptor (MPR300)-dependent endocytosis re...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2009.009
更新日期:2009-01-01 00:00:00
abstract::Here, we describe a novel member in the group of membrane-anchored chymotrypsin (S1)-like serine proteases, namely testis serine protease 1 (T-SP1), as it is principally expressed in testis tissue. The human T-SP1 gene encompasses 28.7 kb on the short arm of chromosome 8 and consists of seven exons. Rapid amplificatio...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2008.170
更新日期:2008-12-01 00:00:00
abstract::In mammalian cells, glucosylceramide (GlcCer), the simplest glycosphingolipid, is hydrolyzed by the lysosomal enzyme acid beta-glucosidase (GlcCerase). In the human metabolic disorder Gaucher disease, GlcCerase activity is significantly decreased owing to one of approximately 200 mutations in the GlcCerase gene. The m...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2008.163
更新日期:2008-11-01 00:00:00
abstract::Fanconi anemia is a fatal, hereditary chromosome instability syndrome of early childhood with progressive pancytopenia and cancer-proneness. Hypersensitivity to alkylating agents points to DNA repair inefficiency. Excess reactive oxygen intermediates and hypersensitivity to oxygen, all features of Fanconi anemia cells...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2008.151
更新日期:2008-10-01 00:00:00
abstract::Abstract The R- and K-gingipain proteases of Porphyromonas gingivalis are involved in proteolysis of haemoglobin from which the defensive dimeric haem pigment is formed. Whilst oxyhaemoglobin is refractory towards K-gingipain, methaemoglobin is rapidly degraded. Ligation of methaemoglobin with N3-, which effectively b...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2008.140
更新日期:2008-09-01 00:00:00
abstract::Neuritic plaques of Alzheimer patients are composed of multiple protein components. Among them, the amyloid beta-peptides (Abeta) 1-40/42 and further N- and C-terminally modified fragments of Abeta are highly abundant. Most prominent are the isoaspartate (isoAsp)-Abeta peptides and pyroglutamyl (pGlu)-Abeta. While pGl...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2008.125
更新日期:2008-08-01 00:00:00
abstract::Consumption of green tea is associated with a decrease in cardiovascular mortality. The beneficial health effects of green tea are attributed in part to polyphenols, organic compounds found in tea that lower blood pressure, reduce body fat, decrease LDL cholesterol, and inhibit inflammation. We hypothesized that epiga...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2008.095
更新日期:2008-07-01 00:00:00
abstract::Stromal cell-derived factor-1alpha (SDF-1alpha) is a strong migratory stimulant for hematopoietic stem and progenitor cells (HSPCs). The hematopoietic cytokines thrombopoietin (TPO), Flt3-ligand (FL), stem cell factor (SCF) and interleukin 11 (IL-11) are able to stimulate amplification of primitive murine hematopoieti...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2008.099
更新日期:2008-07-01 00:00:00
abstract::Kallikrein 6 (KLK6) is a trypsin-like serine peptidase whose relevance in various types of cancers is currently being explored. Previous studies have shown that KLK6 mRNA is upregulated in colon and gastric cancers; however, the regulatory mechanisms and phenotypic consequences of this upregulation are largely unknown...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2008.087
更新日期:2008-06-01 00:00:00